Spanish National Research Council · University of Seville
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Funding for the research activities carried out at IMSE-CNM comes primarily from the participation in competitive tender processes. The research is then conducted out via agreements, projects and contracts with national and international public organizations and private companies and organizations.



MEDACAL-SPHERE
MEDA Wind Sensor Calibration and Spherical Wind Sensor ASIC
PI: Alberto Yúfera García
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Type: Research project
Reference: RTI2018-098728-B-C32
Funding Body: Ministerio de Ciencia, Innovación y Universidades
Start date: 01/01/2019
End date: 31/12/2021
Funding: 176.055,00 €
Abstract: Sub-project MEDACAL-SPHERE has two specific objectives within the coordinated project. Both objectives are connected among them. The first one is to contribute and support the measurements, calibration, and the interpretation of the data obtained from the MEDA wind sensor, which uses a mixed-signal ASIC designed using radiation hardening by design techniques and which performs the conditioning, acquisition and conversion of the sensor signals. This ASIC was developed by the research team in the framework of previous research projects (the MEDA wind-sensor ASIC). The second objective is the design, fabrication and validation of a new mixed-signal ASIC for a new generation of the wind sensor, the so called spherical wind sensor, developed like the previous one by the Polytechnic University of Catalonia. This new version of wind sensor, more accurate than the previous one, will be used as a reference element for the fine calibration of the MEDA wind sensor, which will be sent to Mars, therefore connecting with the first objective. As a result, this new ASIC,which constitutes the second objective, will have the double function of completing the development of the new generation of spherical wind sensors, and serve as a reference for the detailed calibration of the sensors sent to Mars in the framework of NASAs Mars2020.

iSTENT
Real Time Monitoring of Hemodinamic Variables using Smart Stents (iSTENT) based on Capacitive and Bioimpedance Sensors
PI: Alberto Yúfera García
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Type: Research project
Reference: RTI2018-093512-B-C21
Funding Body: Ministerio de Ciencia, Innovación y Universidades
Start date: 01/01/2019
End date: 31/12/2021
Funding: 99.704,00 €
Abstract: The coordinated proposal Real Time Monitoring of Hemodinamic Variables Using Smart Stents (iSTENT) Based on Capacitive and Bioimpedance Sensors aims to progress towards the design and manufacture of microsystems for the real-time monitoring of Intra Stent Restenosis (ISR) and Heart Failure (HF) by means of measuring relevant parameters for the diagnosis of cardiovascular diseases. In short, collaborating to improve the life quality of patients, thanks to the advancement in eHealth, increasing the effectiveness of biomedical monitoring systems.
The SubProject 1 (SP1) Integrated Microsystem based on bioimpedance measurements for the monitoring of arterial restenosis, focuses its work hypothesis on the implementation of electrical bioimpedance measurements to obtain the required useful information of the stent that allows to evaluate the degree of the coronary artery obstruction where it is implanted, as well as the hemodynamic variables involved in its state. The SubProject 2 (SP2) Integrated heterogeneous system for the monitoring of heart failure based on capacitive pressure sensors, proposes to use capacitive MEMS pressure sensors for the monitoring of blood pressure and HF by means of the left ventricle preload. Thus, SP1 pursues the realization of an iStent with the ability to monitor its internal obstruction (ISR) once implanted, avoiding the invasive and high risk procedure for the patient that involves performing a catheterization. Similarly, SP2 proposes the design, characterization and manufacture of an iStent for the monitoring of the HF, based on an heterogeneous integrated circuit for the pressure measurement in the distal pulmonary artery without having to use invasive diagnostic techniques. Besides, both proposals target the adquisition of additional measurements of other hemodynamic variables.

MIXCELL
Integrated MicroSystems for Cell-Culture Assays
PI: Alberto Yúfera García
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Type: Research project
Reference: TEC2013-46242-C3-1-P
Funding Body: Ministerio de Economía y Competitividad
Start date: 01/01/2014
End date: 31/12/2017
Funding: 108.900,00 €
Abstract: This project will be focused on cell-culture monitoring by using impedance and/or capacity measurements. It means a radical change in the conception of the work on cell-culture laboratories, making it possible to supervise an experiment in real-time and remotely during days and, therefore, to increase the measurement sensitivity in many cell-processes like motility and cytotoxicity. The present approach pursues the implementation of integrated CMOS systems for measuring impedance and capacity in cell-cultures in real-time, contributing not only with techniques and strategies but also to the design of high performance integrated circuits: energetic autonomy (LP, LV), capacity for wireless communication, accuracy and bandwidth. The goal of this proposal is to develop new useful analogical front-ends for bio-impedance measurements. In parallel, we will address the problems of characterizing and modeling the employed bio-sensors, and their incorporation into the flow design of the measurement integrated circuits. Our purpose is to evolve towards the concept of on-chip, autonomous systems or laboratories (LoC). The main and final objective, based on the obtained results, will be to achieve a system capable of carrying out the characterization of a cell-culture, establishing a biometric procedure allowing us the identification of different cellular lines and types, characterizing experiments of motility in lines of cancer cells, and evaluating the possibilities of sensing for measuring stem cell proliferation, giving solutions based on electrical resistance and capacity. Our concluding results will be validated with the experimental standards used in biomedical laboratories.
The aims to develop in this project are:
1) Generate techniques and strategies for measuring bio-impedances based on analog signal processing.
2) Design of analog and mixed-signal CMOS integrated systems.
3) Verification of the existing models for the interface sensor-cells and development of new alternatives. Application to simulation, cellular-biometry and microscopy.
4) Experimentation in biomedical labs for monitoring and characterization of cell-cultures, proliferation assays, cancer-cell motility and stem cell proliferation.