Spanish National Research Council · University of Seville
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Funding for the research activities carried out at IMSE-CNM comes primarily from the participation in competitive tender processes. The research is then conducted out via agreements, projects and contracts with national and international public organizations and private companies and organizations.



HEART-FAIL VOLUM
Valor pronóstico en tiempo real para la monitorización del volumen mediante medidas de bioimpedancias en pacientes con insuficiencia cardíaca aguda
PI: Alberto Yúfera García
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Type: Research project
Reference: DTS19/00134
Funding Body: Ministerio de Ciencia, Innovación y Universidades
Start date: 01/01/2020
End date: 21/12/2021
Funding: 46.200,00 €
Abstract: La insuficiencia cardíaca (IC) es la principal causa de hospitalización en personas mayores de 65 años en Europa. La evaluación clínica estándar no permite predecir de forma fiable la evolución de esta enfermedad. La sobrecarga de volumen debido a la activación neuro-hormonal es el principal factor implicado en las hospitalizaciones por IC, y las mediciones de los volúmenes corporales por bioimpedancia (BI) han demostrado de manera preliminar que son útiles en el diagnóstico y pronóstico. Sin embargo, las medidas se realizan puntualmente, o en un período corto, pero la dinámica de la sobrecarga de líquidos en pacientes con IC aguda durante la hospitalización y tras el alta no se han descrito previamente. El objetivo de este estudio es evaluar el valor pronóstico de la monitorización de los volúmenes corporales en tiempo real mediante la medición continua de BI con un nuevo dispositivo portátil para predecir precozmente la evolución clínica en pacientes con IC aguda.


iSTENT
Real Time Monitoring of Hemodinamic Variables using Smart Stents (iSTENT) based on Capacitive and Bioimpedance Sensors
PI: Alberto Yúfera García
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Type: Research project
Reference: RTI2018-093512-B-C21
Funding Body: Ministerio de Ciencia, Innovación y Universidades
Start date: 01/01/2019
End date: 31/12/2021
Funding: 99.704,00 €
Abstract: The coordinated proposal Real Time Monitoring of Hemodinamic Variables Using Smart Stents (iSTENT) Based on Capacitive and Bioimpedance Sensors aims to progress towards the design and manufacture of microsystems for the real-time monitoring of Intra Stent Restenosis (ISR) and Heart Failure (HF) by means of measuring relevant parameters for the diagnosis of cardiovascular diseases. In short, collaborating to improve the life quality of patients, thanks to the advancement in eHealth, increasing the effectiveness of biomedical monitoring systems.
The SubProject 1 (SP1) Integrated Microsystem based on bioimpedance measurements for the monitoring of arterial restenosis, focuses its work hypothesis on the implementation of electrical bioimpedance measurements to obtain the required useful information of the stent that allows to evaluate the degree of the coronary artery obstruction where it is implanted, as well as the hemodynamic variables involved in its state. The SubProject 2 (SP2) Integrated heterogeneous system for the monitoring of heart failure based on capacitive pressure sensors, proposes to use capacitive MEMS pressure sensors for the monitoring of blood pressure and HF by means of the left ventricle preload. Thus, SP1 pursues the realization of an iStent with the ability to monitor its internal obstruction (ISR) once implanted, avoiding the invasive and high risk procedure for the patient that involves performing a catheterization. Similarly, SP2 proposes the design, characterization and manufacture of an iStent for the monitoring of the HF, based on an heterogeneous integrated circuit for the pressure measurement in the distal pulmonary artery without having to use invasive diagnostic techniques. Besides, both proposals target the adquisition of additional measurements of other hemodynamic variables.